| Certain Balance Sheet Items [Abstract] | Period [Axis] |
|---|
2016-01-01 - 2016-12-31 |
|---|
Certain Balance Sheet Items [Abstract] | |
Summary of Accounts Receivable, Net | Accounts receivable, net consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Accounts receivable from revenues under collaborative agreements | | $ | 6,151 |
| | $ | 25,939 |
| Accounts receivable from product sales to collaborators | | 7,854 |
| | 4,996 |
| Accounts receivable from other product sales | | 2,234 |
| | 2,442 |
| Total accounts receivable | | 16,239 |
| | 33,377 |
| Allowance for distribution fees and discounts | | (559 | ) | | (967 | ) | Total accounts receivable, net | | $ | 15,680 |
| | $ | 32,410 |
|
|
Summary of Inventories | Inventories consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Raw materials | | $ | 761 |
| | $ | 677 |
| Work-in-process | | 12,850 |
| | 8,481 |
| Finished goods | | 1,012 |
| | 331 |
| Total inventories | | $ | 14,623 |
| | $ | 9,489 |
|
|
Prepaid Expenses and Other Assets, Current | Prepaid expenses and other assets consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Prepaid manufacturing expenses | | $ | 9,663 |
| | $ | 16,155 |
| Prepaid research and development expenses | | 8,613 |
| | 9,225 |
| Other prepaid expenses | | 1,661 |
| | 1,198 |
| Other assets | | 1,530 |
| | 530 |
| Total prepaid expenses and other assets | | 21,467 |
| | 27,108 |
| Less long-term portion | | 219 |
| | 5,574 |
| Total prepaid expenses and other assets, current | | $ | 21,248 |
| | $ | 21,534 |
|
|
Summary of Property and Equipment, Net | Property and equipment, net consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Research equipment | | $ | 10,479 |
| | $ | 9,666 |
| Computer and office equipment | | 3,373 |
| | 2,570 |
| Leasehold improvements | | 2,331 |
| | 2,025 |
| Subtotal | | 16,183 |
| | 14,261 |
| Accumulated depreciation and amortization | | (11,919 | ) | | (10,318 | ) | Property and equipment, net | | $ | 4,264 |
| | $ | 3,943 |
|
|
Schedule of Accrued Expenses | Accrued expenses consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Accrued compensation and payroll taxes | | $ | 11,539 |
| | $ | 8,636 |
| Accrued outsourced research and development expenses | | 9,522 |
| | 8,617 |
| Accrued outsourced manufacturing expenses | | 3,225 |
| | 6,205 |
| Other accrued expenses | | 4,552 |
| | 4,118 |
| Total accrued expenses | | 28,838 |
| | 27,576 |
| Less long-term accrued outsourced research and development expenses | | 17 |
| | 784 |
| Total accrued expenses, current | | $ | 28,821 |
| | $ | 26,792 |
|
|
Summary of Deferred Revenue | Deferred revenue consisted of the following (in thousands): | | | | | | | | | | | | December 31,
2016 | | December 31,
2015 | Collaborative agreements | | | | | License fees and event-based payments: | | | | | Roche | | $ | 35,709 |
| | $ | 39,038 |
| Other | | 8,209 |
| | 9,724 |
| | | 43,918 |
| | 48,762 |
| Reimbursement for research and development services | | 700 |
| | 4,461 |
| Total deferred revenue | | 44,618 |
| | 53,223 |
| Less current portion | | 4,793 |
| | 9,304 |
| Deferred revenue, net of current portion | | $ | 39,825 |
| | $ | 43,919 |
|
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